1. Over-the-counter (OTC) enzyme use is increasing in frequency in the United States. The numerous health benefit claims by manufacturers are leading to a surge in enzyme use for various conditions and symptoms.

Mayo Clin Proc. 2014 Sep;89(9):1307-12. doi: 10.1016/j.mayocp.2014.05.015. Epub 2014 Aug 4.

2. The effects of enzyme supplementation on performance and digestive parameters of broilers fed corn-soybean diets.

Zhu HL, Hu LL, Hou YQ, Zhang J, Ding BY.

Poult Sci. 2014 Jul;93(7):1704-12. doi: 10.3382/ps.2013-03626. Epub 2014 May 26.

3. Effects of dietary supplementation of multi-enzyme on growth performance, nutrient digestibility, small intestinal digestive enzyme activities.

Zhang GG, Yang ZB, Wang Y, Yang WR, Zhou HJ. J Anim Sci. 2014 May;92(5):2063-9. doi: 10.2527/jas.2013-6672. Epub 2014 Mar 18.

4. Digestive enzyme inhibitors from grains as potential components of nutraceuticals.

Piasecka-Kwiatkowska D, Warchalewski JR, Zielińska-Dawidziak M, Michalak M. J Nutr Sci Vitaminol (Tokyo). 2012;58(3):217-20.

5. An integrative in vitro approach to analyse digestion of wheat polysaccharides and the effect ofenzyme supplementation.

Lafond M, Bouza B, Eyrichine S, Bonnin E, Crost EH, Geraert PA, Giardina T, Ajandouz el H. Br J Nutr. 2011 Jul;106(2):264-73. doi: 10.1017/S0007114511000134.

6. Estimation of intestinal protein digestibility of protein supplements for ruminants using a three-step enzymatic in vitro procedure.

Hippenstiel F, Kivitz A, Benninghoff J, Südekum KH. Arch Anim Nutr. 2015;69(4):310-8. doi: 10.1080/1745039X.2015.1053264. Epub 2015 Jun 9.

7. Digestive Enzyme Supplementation in Gastrointestinal Diseases.

Ianiro G, Pecere S, Giorgio V, Gasbarrini A, Cammarota G. Curr Drug Metab. 2016;17(2):187-93. Review.

8. Digestive enzyme supplementation for autism spectrum disorders: a double-blind randomized controlled trial.

Munasinghe SA, Oliff C, Finn J, Wray JA. J Autism Dev Disord. 2010 Sep;40(9):1131-8. doi: 10.1007/s10803-010-0974-2.

9. Digestive enzyme supplements: replacement therapy for individuals unwilling to take porcine products.

Mayberry JF. Br J Hosp Med (Lond). 2014 Aug;75(8):474-5. doi: 10.12968/hmed.2014.75.8.474. No abstract available.

10. Pancreatic enzyme supplementation for patients receiving enteral feeds.

Ferrie S, Graham C, Hoyle M. Nutr Clin Pract. 2011 Jun;26(3):349-51. doi: 10.1177/0884533611405537. Epub 2011 Apr 20.

11. Stated versus actual lipase activity in pancreatic enzyme supplements: implications for clinical use.

O’Hare MM, McMaster C, Dodge JA.J Pediatr Gastroenterol Nutr. 1995 Jul;21(1):59-63.

12. A novel approach to maintain gut mucosal integrity using an oral enzyme supplement.

Hamarneh SR, Mohamed MM, Economopoulos KP, Morrison SA, Phupitakphol T, Tantillo TJ, Gul SS, Gharedaghi MH, Tao Q, Kaliannan K, Narisawa S, Millán JL, van der Wilden GM, Fagenholz PJ, Malo MS, Hodin RA. Ann Surg. 2014 Oct;260(4):706-14; discussion 714-5. doi: 10.1097/SLA.0000000000000916.

13. Enzyme supplementation in digestive disorders.

FEINBLATT T. \West Med Med J West. 1962 Dec;3:468-72. No abstract available.